Research database
Here you will find all ongoing and completed LROI research projects. Use the search filters to narrow down your selection. Click on the project titles for more details.
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The use of outcome data from quality registries to learn and improve; a Dutch nationwide quantitative analysis in five disease areas
Denissen, GAWProject number: LROI-INTERNAL-2024-010 Starting year: 2024 Published -
Trends in late dislocation incidence (1-15 years) after total hip arthroplasty via the direct anterior vs. the posterolateral approach. A data review of the Dutch Arthroplasty Register (LROI)
Rutger, MProject number: LROI2024-132 Starting year: 2024 Ongoing -
Trends in medial unicompartmental knee arthroplasty in the Netherlands from 2014 to 2021 and their effect on revision: data from the Dutch Arthroplasty Register
Zuiderbaan, HAProject number: LROI2024-135 Starting year: 2024 Ongoing -
Amplify a clinical trial with data from an implant registry
Poolman, RWProject number: LROI2023-112 Starting year: 2023 Ongoing -
Analysis of 516 cases of revision total elbow arthroplasty from the Dutch Arthroplasty Registry: centralization of care is the future
Eygendaal, DProject number: LROI2023-113 Starting year: 2023 Published -
Arthroplasty registries at a glance: an initiative of the International Society of Arthroplasty Registries (ISAR) to facilitate access, understanding, and reporting of registry data from an international perspective
Lübbeke, AProject number: LROI-INT-2025-012 Starting year: 2023 Published -
Concurrent opioid and benzodiazepine prescriptions in hip and knee arthroplasty patients; a growing or a negligible problem? - Association between postoperative benzodiazepine and opioid use and outcomes after hip and knee arthroplasty
Nelissen, RGHH, Gademan MGJStarting date: 1st of december 2023
RGHH Nelissen, MGJ Gademan, A. Dahan, FR Rosendaal, D Broekhuis, ML Bouvy, H Putter
Research proposal abstractIn a previous LROI study we showed that from 2013 until 2018 the prescription of opioids after hip and knee replacement increased. After knee replacement 58% of the patients picked up opioid medication at least once at a pharmacy in 2013 which increased to 89% in 2018. For patient with a hip replacement these numbers increased from 38% to 75%. Inappropriate opioid use may lead to poor outcome after surgery
and addiction of these drugs. Moreover in 2018 in The Netherlands 1.4 million people received a benzodiazepine out of hospital, with the largest user group of both drugs being women aged over 45 years. Both opioids and benzodiazepines are highly addictive substances and have sedating effects. When used alone, they can repress respiratory, impair cognition, slow response times and increase the risk of falling.
It is known that using both drugs together can be very dangerous. Therefore in several guidelines clinicians are warned not to prescribe them together. Nonetheless some studies have shown that patients frequently combine these drugs. However, European studies on this topic are lacking. Moreover it is not clear what the consequences of this concurrent prescriptions are in patients with a hip or knee replacement. In the Netherlands annually >65.000 patients undergo arthroplasty surgery, hence (chronic)
opioid use in combination with benzodiazepines may be substantial, with a major impact on patients’ lives and society. Therefore our aim is to evaluate opioid prescriptions in combination with benzodiazepines patients in with a hip or knee replacement.Project number: LROI-RG-2023-002d Starting year: 2023 Ongoing -
Concurrent opioid and benzodiazepine prescriptions in hip and knee arthroplasty patients; a growing or a negligible problem? - Association of benzodiazepine and (concurrent) opioid use with the risk of arthroplasty because of hip fracture: a nationwide ca
Nelissen, RGHH, Gademan, MGJProject number: LROI-RG-2023-002b Starting year: 2023 Ongoing LROI research grant -
Concurrent opioid and benzodiazepine prescriptions in hip and knee arthroplasty patients; a growing or a negligible problem? - Benzodiazepine and concomitant opioid dispensation before and after hip and knee arthroplasty: a 10 years nationwide study
Nelissen, RGHH, Gademan, MGJProject number: LROI-RG-2023-002a Starting year: 2023 Published -
De schouderprothese in de afgelopen 7 jaar
Gosens, TProject number: LROI-INTERNAL-2023-008 Starting year: 2023 Published -
Difference in TKA and UKA revision rates between “RSA-tested” and “non-RSA-tested” designs in matched patients. A Dutch arthroplasty registry-based study (2007-2022)
Nelissen, RGHHProject number: LROI2022-093 Starting year: 2023 Ongoing -
Distinct age-related modes of failure in cemented and cementless Oxford medial unicompartmental knee arthroplasty: results from 25,762 patients in the Dutch Arthroplasty Register
Zuiderbaan, HAProject number: LROI2023-117 Starting year: 2023 Published -
Do Cumulative Revision Rate and First-time Re-revision Rate Vary Between Short and Standard Femoral Stem Lengths? A Multinational Registry Study
Schreurs, WProject number: LROI2023-110 Starting year: 2023 Ongoing -
Early Periprosthetic Joint Infections in Total Hip and Knee Arthroplasty: Microorganisms, Mortality, and Implant Survival Using a Combined Dataset From the Dutch Arthroplasty Register and the Dutch National Nosocomial Surveillance Network
Schreurs, WProject number: LROI2023-109 Starting year: 2023 Published -
Effect of Cryo- and Compression therapy after Total Knee and Unicompartmental Knee Arthroplasty, a single-blind Randomised Controlled Trial
Brouwer, RWProject number: LROI-RG-2023-004b Starting year: 2023 Ongoing LROI research grant
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