Current trends in the use of megaprosthesis reconstruction (MPR); an analysis from the Dutch Arthroplasty Register
Approval date: December 2024
Starting date: January 13th 2025
RJP van der Wal, M Gademan, RGHH Nelissen
Research proposal abstract
Mega prosthesis replacement (MPR) of the femur is typical reserved for reconstruction after oncological resection for primary bone tumors or metastasis. However, due to their ability to overcome severely diminished bone stock, femoral MPRs also play an established role in the management of select complex revision arthroplasty for aseptic loosening of periprosthetic joint infection (PJI), failed osteosynthesis with non-union of periprosthetic fracture and primary trauma cases.
Advances in MPR design, technologies and surgical techniques mean that mega prostheses now form the mainstay of different limb reconstructions. The rising popularity of mega prostheses can be attributed to their numerous advantageous features including enabling early weight-bearing, swiftly restoring function, and enhancing cosmetic appearances in comparison to alternative treatment approaches.
Trends in indications for, and the outcomes of MPR were very only briefly described on a nationwide level using the data out of joint registries.
To obtain more knowledge on these topics, the aims of this study are to examine
1. the patient demographics
2. indications and trends in usage over time
3. implant survivorship and modes of failure
4. MPR use by different type of hospitals (e.g. tertiary centers, general hospitals).